HIGH PREVALENCE OF DIABETIC KETOACIDOSIS IN CHILDREN WITH NEWLY DIAGNOSED TYPE 1 DIABETES IN BELGRADE, SERBIA: 10-YEAR TERTIARY CENTRE EXPERIENCE
Introduction/Aim: Diabetic ketoacidosis (DKA) is one of the most important causes of acute mortality in youth with type 1 diabetes mellitus (T1DM). Recently published data suggested worryingly high frequency of DKA at the onset of T1DM in Belgrade youth. The goal of this study was to assess the frequency of DKA at the onset of T1DM and the associated risk factors in Belgrade youth during the previous 10 years at a tertiary centre.
Methods: Data were collected retrospectively from the medical records of all children with new-onset T1DM admitted to our centre during the study period between 1st January 2007 and 1st January 2017.
Results: During the study period, a total of 501 subjects (233 girls and 268 boys) were diagnosed with new-onset T1DM, with a mean age of 9.55 ± 4.26 years, and mean pH at the time of diagnosis of 7.28 ± 0.14 (6.78-7.51). Girls with T1DM were younger compared to boys (9.05 ± 4.04 years vs. 9.98 ± 4.41 years, respectively, p < 0.05). Of all patients, 191 (38.1%) presented with DKA, 47.6% of which were classified as mild, 26.2% as moderate and 26.2% as severe DKA. Slightly higher frequency of DKA was noticed in the younger age groups (40%) compared to the children > 11 years (35%), although this difference was not statistically significant.
Conclusion: There is an alarmingly high rate of DKA at the onset of T1DM in Belgrade youth with no significant differences between different age groups. These findings emphasize the need for intensive public health preventive actions aimed at early diagnosis of T1DM in all age groups.
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